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Combo-pilling could be the newest fad or in addition to this the newest into the future under scrutiny and thus it is just more publicly known recently, comb-pilling for weight reduction has been around since the eighties. The biggest reason that by using a combination of pills has become popular is the fact that as of right now there are not any long term prescription weightloss pills that have been licensed by the FDA other than orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications however some of the combinations are actually rejected or have yet to be licensed by the FDA. Seizures can be a side effect with Contrave and shouldn't be taken in people who have seizure disorders. The drug could also raise blood pressure and pulse rate, and shouldn't be used in people with a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy using the drug. The FDA also warned that Contrave can raise blood pressure levels and heartrate and must not used in patients with uncontrolled high blood pressure levels, in addition to by you aren't heart-related and cerebrovascular (circulation dysfunction impacting the mind) disease. Patients using a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes using a boxed warning to alert health care professionals and patients on the increased probability of suicidal thoughts and behaviors related to antidepressant drugs. 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