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This area of the problem regulates reward responses in getting food and sex, plus in nurturing infants and children. One of the most important neurotransmitters linked to reward responses, both when they malfunction and when they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the amount of dopamine released in in response to a stimulus"(Bostwick & Bucci, 2008). Using two separate drugs to shed weight can be very effective there are combinations in front of the FDA now awaiting approval. When dealing with weight loss and the those who go through it one should err on the side of caution and allow the FDA do its job and demand some study be done so the public is aware of the side effects and risks of the medications before we drive them. Keep in mind that drug companies have been in business to earn money and that they would say almost anything to keep people on their own medications. 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The truly disturbing part is that doctors are prescribing these combinations of medications however some of the combinations happen to be rejected or have yet to be licensed by the FDA. Seizures are a side effect with Contrave and shouldn't be taken in individuals with seizure disorders. The drug can also raise blood pressure level and heartbeat, and shouldn't be used in people with a history of cardiac event or stroke in the previous six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with the drug. The FDA also warned that Contrave can raise blood pressure and heart rate and must stop used in patients with uncontrolled high blood pressure level, in addition to by a person with heart-related and cerebrovascular (circulatory dysfunction impacting mental performance) disease. Patients using a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes which has a boxed warning to alert health care professionals and patients towards the increased risk of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for quitting smoking. Approving a drug with this particular many potentially lethal unwanted effects is inconsistent with all the mission statement of the FDA. The power of the drug manufacturing lobby is blatantly evident inside the approval of many drugs requiring 'post-marketing' studies that are clearly significant to overall drug safety within the US.